Side Effects of Melatonin: What Are the Risks?

 Melatonin is a hormone and dietary supplement commonly used as a sleep aid.

Although it has an outstanding safety profile, melatonin’s growing popularity has raised some concerns.

These concerns are mainly due to a lack of research on its long-term effects, as well as its wide-ranging effects as a hormone.

This article reviews the potential side effects of melatonin supplements.

What Is Melatonin?

Melatonin is a neurohormone produced by the pineal glands in the brain, mainly at night.

It prepares the body for sleep and is sometimes called the “hormone of sleep” or “hormone of darkness.”

Melatonin supplements are frequently used as a sleep aid. They help you fall asleep, improve sleep quality and increase sleep duration. However, they don’t appear to be as effective as many other sleep medications (1Trusted Source).

Sleep isn’t the only body function affected by melatonin. This hormone also plays a role in the body’s antioxidant defenses and helps regulate blood pressure, body temperature and cortisol levels, as well as sexual and immune function (2Trusted Source).

In the US, melatonin is available over-the-counter. In contrast, it is a prescription drug in Australia and most European countries and only approved for use in older adults with sleep disorders (3Trusted Source4Trusted Source).

Its use is growing, raising concerns about its possible side effects.

SUMMARYMelatonin is a hormone produced by the brain in response to fading light. It prepares the body for sleep and is often used as a sleep aid.

Does Melatonin Have Any Side Effects?

A few studies have investigated the safety of melatonin, but none have revealed any serious side effects. It also doesn’t seem to cause any dependence or withdrawal symptoms (5Trusted Source6Trusted Source).

Nonetheless, some medical practitioners are concerned that it may reduce the natural production of melatonin in the body, but short-term studies suggest no such effects (7Trusted Source8Trusted Source9Trusted Source).

Several studies have reported general symptoms, including dizziness, headache, nausea or agitation. However, these were equally common in the treatment and placebo groups and couldn’t be attributed to melatonin (5Trusted Source).

Melatonin supplements are generally considered safe in the short-term, even when taken in very high doses. However, more research on its long-term safety is needed, especially in children (10Trusted Source).

A few mild side effects and drug interactions are discussed in the chapters below.

SUMMARYMelatonin supplements are considered safe, and no studies have revealed any serious side effects to date. Yet, more research is needed to evaluate its long-term effects.

Use in Children

Parents sometimes give melatonin supplements to children who have trouble falling asleep (11Trusted Source).

However, the FDA has neither approved its use nor evaluated its safety in children.

In Europe, melatonin supplements are a prescription-only medicine intended for adults. Yet, one Norwegian study found that their unapproved use in children was on the rise (4Trusted Source).

While there is no specific cause for concern, many experts are reluctant to recommend this supplement for children.

This reluctance stems in part from its wide-ranging effects, which are not completely understood. Children are also considered a sensitive group, as they are still growing and developing.

Long-term studies are needed before melatonin can be used with absolute safety in children (12Trusted Source).

SUMMARYWhile parents occasionally give melatonin supplements to their children, most health practitioners don’t recommend its use in this age group.

Daytime Sleepiness

As a sleep aid, melatonin supplements should be taken in the evening.

When taken at other times of the day, they may cause undesirable sleepiness. Keep in mind that sleepiness is technically not a side effect but rather their intended function (13Trusted Source14Trusted Source).

Nevertheless, sleepiness is a possible problem in people who have reduced melatonin clearance rates, which is the rate at which a drug is removed from the body. An impaired clearance rate extends the time melatonin levels stay high after taking supplements.

While this may not be an issue in most healthy adults, reduced melatonin clearance has been reported in older adults and infants. It is unknown whether this has any effects on melatonin levels the morning after taking supplements (15Trusted Source16Trusted Source).

Yet, even when melatonin supplements or injections are given during the daytime, they do not seem to affect the ability to maintain focus.

Studies in healthy people injected with 10 or 100 mg of melatonin or given 5 mg by mouth found no effects on reaction times, attention, concentration or driving performance, compared to a placebo (14Trusted Source17Trusted Source).

More studies are needed before scientists can fully understand the effects of melatonin supplements on daytime sleepiness.

SUMMARYMelatonin supplements may cause daytime sleepiness when taken during the day. You should only use melatonin in the evening.

Other Concerns

Several other concerns have been raised, but most have not been thoroughly researched.

  • Interaction with sleeping pills: One study found that taking the sleep medication zolpidem along with melatonin exacerbated zolpidem’s adverse effects on memory and muscle performance (18Trusted Source).
  • Decreased body temperature: Melatonin causes a slight drop in body temperature. While this is generally not a problem, it could make a difference in people who have difficulty keeping warm (19Trusted Source).
  • Blood thinning: Melatonin may also reduce blood coagulation. As a result, you should speak with your doctor before taking high doses of it with warfarin or other blood thinners (20Trusted Source).
SUMMARYMelatonin may interact with medications, such as sleeping pills, and can act as a blood thinner when taken in high doses.

How to Supplement With Melatonin

To aid sleep, the standard dosage ranges from 1 to 10 milligrams per day. However, the optimal dose has not been formally established (21Trusted Source).

Since not all melatonin supplements are the same, make sure to follow the instructions on the label.

Also, keep in mind that the quality of over-the-counter supplements is not monitored by health authorities. Try to choose brands that are reputable and certified by a third party, such as Informed Choice and NSF International.

Many experts do not recommend their use in children and adolescents until more evidence confirms its safety in these groups (5Trusted Source).

Since melatonin is transferred into breast milk, breastfeeding mothers should keep in mind that it might cause excessive daytime sleepiness in nursing infants (22Trusted Source).


The common dosage of melatonin ranges from 1–10 mg per day, but make sure to follow the instructions on the label. Parents should not give it to their children without first consulting their medical provider.

How to Increase Melatonin Levels Naturally

Luckily, you can increase your melatonin levels without supplementing.

A few hours before bedtime, simply dim all lights at home and avoid watching TV and using your computer or smartphone.

Too much artificial light can reduce the production of melatonin in the brain, making it harder for you to fall asleep (23Trusted Source).

You can also strengthen your sleep-wake cycle by exposing yourself to plenty of natural light during the day, especially in the morning (24Trusted Source).

Other factors that have been associated with lower natural melatonin levels include stress and shift work.

SUMMARYFortunately, you can increase your natural melatonin production naturally by sticking to a regular sleep schedule and avoiding artificial light late in the evening.

The Bottom Line

Melatonin supplements haven’t been linked to any serious side effects, even at very high doses.

However, most experts agree that more research on its long-term safety is needed.

Thus, sensitive individuals, such as children and pregnant or breastfeeding women, should consult their doctors before taking it.

Even so, melatonin has an excellent safety profile and appears to be an effective sleep aid. If you often experience poor sleep, it may be worth trying.

JPeei Clinic